The effect of the depressant galactomannan or fenugreek powder gum indicates that the flotation results show fenugreek gum had a straining influence on the depression of talc while had little effect on nickel minerals flotation. Compared with the depressant carboxymethyl cellulose (CMC) and guar gum, the fenugreek gum increased the nickel recovery dramatically, it not only negated the need for a talc removal process but also achieved a significant decrease in the depressant consumption by half. Zeta-potential and infrared spectrum measurements illustrated that chemical adsorption was seen between KGM and talc, and a possible weak physical adsorption was seen between KGM and pentlandite. This was the reason why KGM had high depression selectivity for talc and little depression effect on nickel minerals.